Recently I came across a scenario where customer reported that he installed application on new server with all software upgraded to their latest versions (including browsers) and suddenly he saw UI taking 20 seconds to load, and sometimes gave a script timeout error. Application was developed using GWT. After trying out many things, starting the browsers in safe mode helped and the UI load time reduced from 20 to 2-3 seconds.
Below are some of the steps that helped us speed up the thing. In case you have any other ideas/comments, please post in the comment section.